What is Meridia 15 mg?
Meridia 15 mg contained sibutramine, an appetite-suppressant originally approved for obesity treatment. Sibutramine acted on the central nervous system, increasing levels of serotonin and noradrenaline, leading to reduced hunger and enhanced satiety.
Despite its early popularity, clinical trials later revealed serious cardiovascular risks, which led to its global withdrawal.
Ingredients of Meridia 15 mg
Active ingredient:
- Sibutramine hydrochloride monohydrate.
Excipients include:
- microcrystalline cellulose
- lactose monohydrate
- magnesium stearate
- gelatin
- capsule colorants
How does sibutramine work?
Sibutramine works by inhibiting the reuptake of:
serotonin
noradrenaline
dopamine (partially)
This results in:
appetite reduction
earlier satiety
mild increase in metabolic rate
Cardiovascular risks:
The SCOUT clinical trial confirmed that sibutramine significantly increases the risk of:
heart attack
stroke
elevated blood pressure
